Validation of the liquid chromatography-comprehensive multidimensional gas chromatography-time-of-flight mass spectrometer/flame ionization detector platform for mineral oil analysis exploiting interlaboratory comparison data

Mineral oils, classified into two main fractions, namely saturated (MOSH) and aromatic hydrocarbons (MOAH), originate from petroleum. Their determination in food is challenging due to the difficulty of isolating them matrix presence natural interferences, leading low reproducibility results among different laboratories. Therefore, standardized procedures are highly required minimize uncertainty caused by various sources (e.g., integration, interference removal, etc.). However, at present, a few sample preparation have been standardized, while analytical mainly performed using hyphenated liquid-gas chromatographic technique coupled with flame ionization detector (LC-GC-FID). LC-GC-FID still not enough for confirmatory purposes, which use comprehensive 2D GC (GC × GC) has suggested. Recently, fully integrated platform routine purposes proposed Bauwens co-workers (2022), LC-GC GC-time-of-flight mass spectrometer (ToFMS)/FID. The aim this work validate quantification MOSH MOAH GC-FID supported recently developed integration software. validation was taking advantage participation several organized interlaboratory comparisons Joint Research Center (to harmonize method infant formula products) German Society Fat Science French Technical Institute Study Fats improve European fats, i.e. EN 16995:2017). Data obtained were good agreement those ILCs, terms recovery, precision, accuracy, repeatability.